解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils which are derived from different proteins in different forms of the disease. Asymptomatic amyloid deposition in a variety of tissues is a universal accompaniment of ageing, and clinical amyloidosis i...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.1994.tb00001.x
更新日期:1994-11-01 00:00:00
abstract::The relationship between proliferating cell nuclear antigen (PCNA) expression and various clinicopathological indices (age, sex, tumour location, histological type and grade and treatment) and post-operative survival were studied in patients with central nervous system gliomas using univariate and multivariate analysi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01353.x
更新日期:1994-10-01 00:00:00
abstract::Human T-cell leukaemia/lymphoma virus type 1 (HTLV-1), a causative virus of adult T-cell leukaemia/lymphoma (ATLL), is known to be transmitted by breast-feeding. Using a monoclonal antibody HML-1 which labels human intestinal intra-epithelial T lymphocytes, we have immunohistochemically examined ATLL tissues in order ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01322.x
更新日期:1994-09-01 00:00:00
abstract::Expression of tenascin, type IV collagen and laminin during human intrahepatic bile duct development and in cholangiocarcinoma was examined by immunohistochemistry. In the developing hilar bile ducts, tenascin was expressed in the mesenchyme around the epithelial cells migrating from the ductal plate into the mesenchy...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01570.x
更新日期:1994-08-01 00:00:00
abstract::Pulmonary blastomas and carcinosarcomas are uncommon tumours, accounting for less than 1% of all lung neoplasms. Three previously described mixed epithelial and mesenchymal tumours having both adult and embryonal elements were termed 'transitional'. We report a similar case and evaluate the application of the term 'tr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01574.x
更新日期:1994-08-01 00:00:00
abstract::We report a primary non-Hodgkin's B-cell lymphoma of the urethra in a 78-year-old female. Serum antibodies for Epstein-Barr virus (EBV) were negative, but there was a 40-fold increase in antibodies to EBV-associated nuclear antigen. Using PCR and in situ hybridization techniques, EBV genome was found in the tumour cel...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00570.x
更新日期:1994-06-01 00:00:00
abstract::While the histological grade of a renal cell carcinoma is of prognostic significance there is poor concordance amongst pathologists in the use of these grading systems. Many grading systems have been described, but none has achieved widespread acceptance. The objective of this study was to assess the degree of interob...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00557.x
更新日期:1994-05-01 00:00:00
abstract::In view of the critical role of dendritic cells in immune mediated skin diseases, we have investigated the membrane antigen patterns and ultrastructure of cutaneous dendritic cells in eight patients with chronic discoid lupus erythematosus and five with subacute cutaneous lupus erythematosus. In the lesional epidermis...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb00531.x
更新日期:1994-04-01 00:00:00
abstract::Fifteen hamartomas of the breast have been studied by dissecting microscopy of thick sections at a depth of 1.0 to 2.5 mm, and by conventional 5 microns deep sections. This combined approach has revealed six distinctive features, three in the parenchymal structure and three in the connective tissue components. Ducts (...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01296.x
更新日期:1994-02-01 00:00:00
abstract::In recent years the interaction between tumour cells and the surrounding extracellular matrix in the process of tumour development, invasion and metastasis has been a focus of interest. We studied frozen sections of nine naevocellular naevi (junctional, compound and intradermal), 40 dysplastic naevi, six pagetoid in s...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01268.x
更新日期:1994-01-01 00:00:00
abstract::Waldeyer ring lymphomas belong to a category of tumours which has not yet been fully defined. Their relation to mucosa-associated lymphoid tissue (MALT) and other extranodal lymphomas remains largely unknown. We performed a clinicopathological retrospective study of 79 patients, and compared them with a series of MALT...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1994.tb01266.x
更新日期:1994-01-01 00:00:00
abstract::Hyaline eosinophilic globules have so far been described in a restricted variety of tumour types. We have noted their presence in a variety of gynaecological malignancies, in particular mixed Müllerian tumours and other epithelial ovarian tumours. We therefore studied their incidence and distribution in a series of ma...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01244.x
更新日期:1993-12-01 00:00:00
abstract::12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue. The diagnostic utility of 12E7 as a marker of Ewing's sarcoma and peripheral neuroectodermal tumour was assessed. Immunocytochemical studies were performed on 120 small round-cell tumours from childre...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01243.x
更新日期:1993-12-01 00:00:00
abstract::The DNA content in gallbladder carcinoma and its relation to histological and cytological features was studied in 79 primary gallbladder carcinomas and 16 metastases. Abnormal DNA content was observed in 48 (51%) of 95 cases. In primary carcinomas, 44 (55.6%) showed a diploid DNA content, and 35 (44.4%) were aneuploid...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00495.x
更新日期:1993-11-01 00:00:00
abstract::Twenty-eight patients with a diagnosis of either atypical or malignant meningioma, according to the World Health Organisation (WHO) classification, were followed up to relate histopathological features with times to recurrence and death. Five year disease-free survival was 41% with a median disease free survival of 27...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01218.x
更新日期:1993-10-01 00:00:00
abstract::One hundred and twenty-six radial scars and complex sclerosing lesions from 91 women were examined to determine the incidence of and the clinical and pathological factors associated with the development of carcinoma and atypical hyperplasia within them. There was a clear relationship between the presence of carcinoma ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb01194.x
更新日期:1993-09-01 00:00:00
abstract::A total of 118 biopsies from 20 different types of benign, malignant and reactive vascular proliferations were examined for the expression of the CD30 antigen using the monoclonal antibodies BerH2 and HRS4 on paraffin-embedded sections. The results were compared with those obtained using an antibody directed against t...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00476.x
更新日期:1993-08-01 00:00:00
abstract::This study evaluates the usefulness of a combined cytological and histological approach to the diagnosis of hepatocellular carcinoma (HCC) when applied to fine needle biopsy specimens obtained under ultrasonic guidance. The material, aspirated from 51 focal liver lesions, was handled in such a way that there was suffi...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00180.x
更新日期:1993-06-01 00:00:00
abstract::We report a case of oesophageal carcinosarcoma with prominent rhabdomyoblastic differentiation. Immunohistochemically, the rhabdomyblasts were mainly reactive to vimentin, cytokeratin, desmin, muscle-specific actin, myosin, and myoglobin, and were surrounded by laminin and type IV collagen-positive basement membranes....
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00164.x
更新日期:1993-05-01 00:00:00
abstract::Chronic inflammatory cells are a recognized component of atherosclerotic plaques at all stages of development. As adhesion molecules play a fundamental role in inflammatory processes, we have carried out an immunohistochemical investigation of the distribution of endothelial leucocyte adhesion molecule-1 (ELAM-1)*, in...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00157.x
更新日期:1993-05-01 00:00:00
abstract::Signet ring cell differentiation in adenocarcinoma of the prostate is uncommon. In a review of 200 cases of prostatic carcinoma, we identified five cases with this change, all in moderately to poorly differentiated prostatic carcinomas. The signet ring cells in prostatic carcinoma contain an intracytoplasmic lumen, sh...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00137.x
更新日期:1993-04-01 00:00:00
abstract::Acquired Hirschsprung's disease is a rare and controversial form of colonic aganglionosis. Little is known about its aetiology and pathogenesis. We report five cases encountered amongst 173 long-term follow-up patients treated for classical Hirschsprung's disease between 1957 and 1990 at the Red Cross Children's Hospi...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.1993.tb00096.x
更新日期:1993-02-01 00:00:00
abstract::We have investigated the immunohistochemical expression of p53 protein in 96 cases of non-Hodgkin's lymphoma using a panel of five antibodies. Positive neoplastic cells were found in 30 (31.2%) cases, which could be divided into two groups according to their patterns of reactivity with the different antibodies; i.e. t...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00067.x
更新日期:1993-01-01 00:00:00
abstract::A series of 115 consecutive, non-ulcerous, dyspeptic patients were examined for Helicobacter pylori (H. pylori) colonization in the gastric antral and/or body mucosa using Giemsa staining. Findings were correlated with the presence and degree of activity of superficial gastritis, deep gastritis, atrophic gastritis and...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1993.tb00062.x
更新日期:1993-01-01 00:00:00
abstract::A total of 144 gastric biopsies colonized by Helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. Biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) an...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00439.x
更新日期:1992-12-01 00:00:00
abstract::Calcitonin is a hypocalcaemia producing hormone and is secreted by C-cells of the thyroid. The current study was undertaken on a hypothesis that C-cell hyperplasia may develop in the secondary hyperparathyroidism of chronic renal failure in response to sustained hypercalcaemia. With an immunoperoxidase staining method...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00433.x
更新日期:1992-11-01 00:00:00
abstract::The stereological estimate of mean nuclear volume is an objective and reproducible method of measurement of nuclear size in terms of absolute volume. We have used this method to study carcinomas of the ampulla of Vater. Our study includes 21 cases--five papillary and 16 intestinal--all treated by the same surgical pro...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00382.x
更新日期:1992-09-01 00:00:00
abstract::A mapping study of cystectomy specimens in three cases of pure squamous cell carcinoma and 28 cases with transitional cell carcinoma with squamous differentiation is described, with an emphasis on the histogenesis of pure squamous cell carcinoma. Two of the three cases of pure squamous cell carcinoma had extensive ben...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00361.x
更新日期:1992-08-01 00:00:00
abstract::Eleven hepatoblastomas of various subtypes and normal liver tissue were investigated with antibodies against collagen types I-VI, laminin, fibronectin and endothelial and macrophage-associated antigens. Epithelial hepatoblastoma cells, unlike non-neoplastic hepatocytes, exhibited intracellular immunoreactivity for var...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00359.x
更新日期:1992-08-01 00:00:00
abstract::Eleven colloid cysts of the third ventricle were investigated by immunohistochemistry using 16 mono- and polyclonal antibodies. Colloid cyst epithelium, choroid plexus epithelium and ependyma showed different immunohistochemical profiles. In particular, antibodies to different cytokeratins and to transthyretin reveale...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00340.x
更新日期:1992-07-01 00:00:00
abstract::We report a case of primary extrarenal Wilms' tumour which, on histological examination, revealed a zone of hyalinized blastema adjacent to, and within the tumour capsule. The tumour showed a predominant stromal component. The presence of the hyalinized blastema adjacent to the tumour raises the possibility that some ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00348.x
更新日期:1992-07-01 00:00:00
abstract::The inflammatory infiltrate has been characterized in 10 cases of ovarian dysgerminoma using a panel of antisera to T-cells, B-cells and macrophages. The expression of Class II major histocompatibility complex (MHC) antigens and the distribution of interferons alpha and gamma were also examined. T-lymphocytes were pre...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb01033.x
更新日期:1992-06-01 00:00:00
abstract::The post-transplant lymphoproliferative disorders represent a spectrum of life-threatening, generally Epstein-Barr virus-associated lymphoid proliferations which occur in the setting of exogenous immunosuppression following organ transplantation. Histopathological, phenotypic, genotypic and Epstein-Barr virus studies ...
journal_title:Histopathology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2559.1992.tb01007.x
更新日期:1992-05-01 00:00:00
abstract::HLA-DR expression was examined in 50 consecutive primary cutaneous malignant melanomas with a Breslow depth greater than 2 mm using two well-characterized monoclonal antibodies which detect fixation-resistant epitopes. In 31 of these cases (62%) a subpopulation of tumour cells was reactive, although there was consider...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb01011.x
更新日期:1992-05-01 00:00:00
abstract::Delta hepatitis (HDV) infection can only occur in the presence of hepatitis B (HBV) infection, as HDV requires a coat of HBV surface antigen (HBsAg) for assembly of complete virus. A number of studies have examined the variation of HBV markers in serum and liver during establishment of HDV infection, but none has syst...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00990.x
更新日期:1992-04-01 00:00:00
abstract::An immunohistochemical study of non-small cell lung carcinoma using PC10, a monoclonal antibody against PCNA, was performed on tissues routinely processed with formalin fixation and paraffin embedding. The PCNA labelling index and mitotic index were determined from sections of these tissues. Tumours showed a high mean...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00964.x
更新日期:1992-03-01 00:00:00
abstract::Epidermolysis bullosa, a rare genodermatosis, is characterized by increased skin fragility manifest as blistering and sometimes accompanied by scarring. The latter is particularly severe in the recessive dystrophic variant and may be complicated by the development of squamous carcinoma in up to 30% of patients. We hav...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00962.x
更新日期:1992-03-01 00:00:00
abstract::Immunohistochemical studies on renal biopsies from eight patients with various types of glomerulonephritis showed that the interstitial foam cells belonged to the monocyte-macrophage lineage. There was a strong association between hypercholesterolaemia and the presence of renal interstitial foam cells. ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1992.tb00949.x
更新日期:1992-02-01 00:00:00
abstract::One hundred and eighty-seven operable lung tumours were immunostained with the monoclonal antibody Ki-67 and divided into groups of high, moderate or low proliferation. Patients have been followed clinically for up to 7 years to ascertain whether this immunocytochemical measurement reflected tumour behaviour in terms ...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb01503.x
更新日期:1991-12-01 00:00:00
abstract::Five antibodies, MT1 (CD43), UCHL1 (CD45RO), OPD4, poly-CD3 and beta F1, were assessed for their reactivity with 50 archival cases of T-cell lymphoma in formalin-fixed paraffin-embedded tissue. All cases had been previously characterized as T-cell lymphomas, and the histological types included 14 cases of small cerebr...
journal_title:Histopathology
pub_type: 杂志文章
doi:10.1111/j.1365-2559.1991.tb00231.x
更新日期:1991-11-01 00:00:00